Pleural Mesothelioma
Pleural mesothelioma is a malignant cancer that
develops on the lining of the lungs called the pleura. It is the most
common type of mesothelioma. Although the prognosis is typically poor,
finding a pleural cancer specialist can diversify your treatment options
and help improve your prognosis.
Learn About Pleural Mesothelioma with Our Free Guide
Free information, books, wristbands and more for patients and caregivers.Get Yours Today
Pleural mesothelioma accounts for about 75 percent of all
mesothelioma cases. Like other types of mesothelioma, this particular
form of the disease gets its name because of where it is formed — in the
pleura, a soft tissue that surrounds the lungs. In almost all cases,
pleural mesothelioma is caused by asbestos exposure.
The first symptoms of pleural mesothelioma typically include chest
pain and shortness of breath. You may experience no symptoms at all in
the first few stages of the cancer’s progression.
The life expectancy
of someone with pleural mesothelioma is less than 18 months, but some
patients live much longer. It often takes decades (20 to 50 years) for
mesothelioma to develop after someone is first exposed to asbestos. This
lag time — called a latency period — explains why the disease usually
affects older people.
How Asbestos Leads to Mesothelioma
Once inhaled into the lungs, asbestos travels to the pleura. The body then struggles to get rid of the needle-like fibers. Over a long period of time, trapped fibers irritate the pleural membrane, causing chronic inflammation and scarring.Odds of Development
In 2 to 10 percent of people heavily exposed to asbestos, the trapped fibers cause pleural mesothelioma by triggering genetic changes in cells that make up the pleura. These cancerous cells grow fast and uncontrollably, forming tumors that wrap around the lungs.Who Is Affected?
About 80 percent of people diagnosed with pleural mesothelioma are older men, mainly because most asbestos exposure occurred at industrial jobs traditionally worked by men.What Are Pleural Mesothelioma Symptoms?
Symptoms of pleural mesothelioma include persistent dry or raspy
cough, coughing up blood (hemoptysis), shortness of breath (dyspnea),
and difficulty swallowing (dysphagia). There are four stages of mesothelioma
that doctors use to describe how far the cancer has progressed. For
many people, unfortunately, symptoms are not noticeable until the cancer
is in a later stage — stage III or IV.
Asbestos fibers can cause excess fluid to build up between the two layers of the pleura, a condition called pleural effusion.
While a little fluid in your pleural space is important, too much can
make breathing difficult. The extra fluid puts pressure on the lungs,
causing chest pain that gets worse when you cough or take deep breaths.
Tumor Complications Are Largely Responsible for Symptoms, Which May Include:
- Persistent dry or raspy cough
- Coughing up blood (hemoptysis)
- Shortness of breath (dyspnea)
- Pain in the lower back or rib area
- Painful breathing
- Lumps under the skin on the chest
- Difficulty with swallowing (dysphagia)
- Night sweats or fever
- Unexplained weight loss
- Fatigue
Compensation for Pleural Mesothelioma Victims
Gain access to trust funds, grants and other forms of compensation for you or your loved ones.
Get Help Now
Diagnosis
Two layers of tissue make up the pleura. These tissues
protect and support the lungs and other important structures of the
chest. They also produce lubricating fluid between to help the lungs
move smoothly as we breathe. The outer layer, the parietal pleura, lines
the entire inside of the chest cavity.
The inner layer, or visceral pleura, covers the lungs.
Mesothelioma commonly affects both layers of the pleura. The cancer generally forms in one layer of the pleura and rapidly invades the other pleural layer, diaphragm, chest wall or lung. If the cancer reaches nearby glands called lymph nodes, it can metastasize, or spread, to other parts of the body.
Non-cancerous conditions like pleural plaques and atelactasis can develop on the surface of the pleura as a result of asbestos exposure and these conditions are not associated with pleural mesothelioma. They don’t develop into cancer and they don’t increase the risk of developing lung cancer or pleural mesothelioma.
Mesothelioma commonly affects both layers of the pleura. The cancer generally forms in one layer of the pleura and rapidly invades the other pleural layer, diaphragm, chest wall or lung. If the cancer reaches nearby glands called lymph nodes, it can metastasize, or spread, to other parts of the body.
Non-cancerous conditions like pleural plaques and atelactasis can develop on the surface of the pleura as a result of asbestos exposure and these conditions are not associated with pleural mesothelioma. They don’t develop into cancer and they don’t increase the risk of developing lung cancer or pleural mesothelioma.
Difficult to Confirm a Diagnosis
It is challenging for doctors to tell the difference between pleural mesothelioma and lung cancer. While doctors may suspect mesothelioma based on a patient's symptoms, history of asbestos exposure and irregular imaging scan results, these signs are not enough to confirm a diagnosis.Reliable Ways to Diagnose
More reliable ways to diagnose the disease include thoracoscopy, which allows doctors to view the patient's chest through a small camera and collect a tissue biopsy, which doctors use to test tissue and fluid samples for cancerous cells.Diagnostic Imaging
To achieve the best treatment options and survival outlook, an early diagnosis
is crucial. After a review of medical and occupational history and a
physical examination, patients typically undergo imaging tests that can
reveal potentially cancerous tumors. There are three primary imaging
tests used to diagnose pleural mesothelioma: Chest X-rays, CT Scans, and
PET Scans.
Chest X-rays
X-rays can reveal pleural effusions and pleural-based masses in some cases.
CT Scans
CT scans provide more advanced images that often show evidence of asbestos exposure.
PET Scans
PET scans can also detect signs of cancerous spread to the lymph nodes.
Cytology and Biopsy
Other tests are needed to diagnose mesothelioma with a high
level of confidence. One test is thoracentesis, in which doctors insert a
hollow needle into the lungs to collect pleural fluid.
Doctors look at the cell samples from the fluid under a microscope. They look for substances called biomarkers that indicate the presence of cancer. Specialists can use this analysis to make an accurate diagnosis in 80 percent of malignant mesothelioma cases.
Doctors look at the cell samples from the fluid under a microscope. They look for substances called biomarkers that indicate the presence of cancer. Specialists can use this analysis to make an accurate diagnosis in 80 percent of malignant mesothelioma cases.
If a series of tests or biopsies confirm the presence of mesothelioma, doctors develop a treatment plan based on the results.
Similar diagnostic tests will be performed on different parts of the body for other forms of mesothelioma. For example, even though similar imaging scans and biopsies are used to diagnose all types of mesothelioma, the part of the body that undergoes imaging or biopsy will differ for each type of mesothelioma.
Because mesothelioma locally invades the body cavity in which it develops before spreading, doctors rarely have a hard time differentiating one form of mesothelioma from another. Only in late stage IV cases may there be enough spreading to or from the lung to the abdomen to question whether the cancer originated in the lining of the lungs or abdomen.
Learn more about mesothelioma diagnosis
Treatment Options
Get the Best Treatment
Get help connecting with the nation's top pleural mesothelioma doctors and cancer centers.Get Help Now
Depending on how far your mesothelioma has progressed, these therapies can be either either cytoreductive (meaning reduction of tumor cells) or palliative (meaning control of symptoms).
Cytoreductive treatments aim to control the cancer, while palliative treatments only address the symptoms and try to improve the quality of life for patients.
The most common treatments for pleural mesothelioma are the following:
- Surgery
- Chemotherapy
- Radiation
- Mulitmodal
Next Type
Learn more about pleural mesothelioma treatments
Questions About Pleural Mesothelioma?
Chat with one of our Patient Advocates for help finding a specialized pleural mesothelioma treatment center near you.
Chat Now
Complementary Therapies
Some people with pleural mesothelioma take an integrative approach to treatment by combining complementary therapies with traditional cancer treatment. While complementary therapies cannot cure pleural mesothelioma, they can ease cancer symptoms and reduce side effects of cancer treatment.For example, certain herbs like slippery elm bark may help relieve a cough and pulmonary discomfort. Some yoga breathing techniques may feel soothing to the lungs and most offer a sense of relaxation to ease stress. Mental health counseling is the most effective therapy for psychological stress.
Acupuncture and acupressure are clinically proven to help control nausea and vomiting caused by chemotherapy. Other complementary therapies used in cancer care include:
- Nutrition
- Meditation
- Tai chi and qigong
- Osteopathic medicine
Prognosis
After the diagnostic process, doctors analyze the expected course and outcome for the disease — your prognosis.
While some cancers carry promising prognoses, malignant mesotheliomas
do not. Providing an accurate prognosis challenges doctors because the
disease is so complex and aggressive.
Factors That Affect Your Prognosis
- Stage of disease at diagnosis
- Age of patient
- Gender of patient
- Patient's smoking history
- Painful breathing
The most important factor in a pleural mesothelioma prognosis is
the stage of the disease at diagnosis. Staging is how doctors describe
cancer's progression. An early stage cancer offers a better change of
long-term survival than a late-stage cancer. Patients in otherwise good
health who can still perform normal daily tasks tend to respond better
to treatment, which is also a significant factor for survival.
Other important prognostic factors include your
age, sex and smoking history. Generally speaking, survival rates are
higher for female patients, non-smokers and patients younger than 55. A
cancerous tumor's cellular makeup — called histology — also can have a
major influence on prognosis.
Subtypes
Among the subtypes of this disease, epithelial mesothelioma makes up the most cases (50 to 70 percent) and also offers the most long-term hope.Pleural Mesothelioma Survival Rate by Year
- 40% Survive one year after diagnosis.
- 20% Survive two or more years after diagnosis.
- 10% Survive three years after diagnosis.
Patients with epithelial mesothelioma respond best to treatment and
typically live at least one year. Other subtypes like sarcomatoid and
biphasic mesothelioma have poorer survival rates, usually around six or
eight months.
Sarcomatoid cells are the most aggressive mesothelioma cells in terms of rapid growth and resistance to treatments like chemotherapy. Because biphasic mesothelioma is a mix of both epithelial and sarcomatoid cells, how a patient responds to treatment and how long they live will depend upon the percentages of epithelial and sarcomatoid cells. A higher ratio of epithelial cells translates into longer survival.
Sarcomatoid cells are the most aggressive mesothelioma cells in terms of rapid growth and resistance to treatments like chemotherapy. Because biphasic mesothelioma is a mix of both epithelial and sarcomatoid cells, how a patient responds to treatment and how long they live will depend upon the percentages of epithelial and sarcomatoid cells. A higher ratio of epithelial cells translates into longer survival.
Additional Resources
Author
Karen Selby
Karen Selby is a registered nurse and a
Patient Advocate at The Mesothelioma Center. She worked in several
subspecialties within nursing before joining Asbestos.com in 2009.